订货信息 |
产品货号 | RP1006 |
产品规格 | 500 µg |
产品信息 |
产品名称 |
重组人胎球蛋白B( Recombinant Human Fetuin B) |
别名 | 16G2, Gugu, IRL685 |
Accession Number | NP_055190 |
Gene ID | 26998 |
氨基酸序列 | MSPPQLALNP SALLSRGCND SDVLAVAGFA LRDINKDRKD GYVLRLNRVN DAQEYRRGGL GSLFYLTLDV
LETDCHVLRK KAWQDCGMRI FFESVYGQCK AIFYMNNPSR VLYLAAYNCT LRPVSKKKIY MTCPDCPSSI
PTDSSNHQVL EAATESLAKY NNENTSKQYS LFKVTRASSQ WVVGPSYFVE YLIKESPCTK SQASSCSLQS
SDSVPVGLCK GSLTRTHWEK FVSVTCDFFE SQAPATGSEN SAVNQKPTNL PKVEESQQKN TPPTDSPSKA
GPRGSVQYLP DLDDKNSQEK GPQEAFPVHL DLTTNPQGET LDISFLFLEP MEEKLVVLPF PKEKARTAEC
PGPAQNASPL VLPP |
表达宿主 | HEK293 |
分子量 | 预测分子量为41Kda,受糖基化的影响,还原SDS-PAGE上分子量大小约为55-58 kDa。 |
标签 | Tag Free |
形态 | 液体 |
纯化方法 | 层析纯化 |
缓体体系 | 1×PBS, pH 7.4 |
保存条件 | -20℃ |
产品质量 |
无菌检测 | 合格 |
支原体检测 | 合格 |
内毒素水平 | <0.01EU/µg |
纯度 | ≥95%,采用 SDS-PAGE 凝胶分析(图1)及HPLC分析 |
活性 | 通过抑制组织蛋白酶 V(CathepsinV) 裂解荧光肽底物 Z-LR-AMC (RLU) 的能力来确定。 IC50≤100nM。 |
参考文献
1. Li XY, Wang X, Gu ZY, Sun TT, Leng JH, Yu Q. Combined proteomics and
transcriptomics identifies serpin family C member 1 associated protein as a
biomarker of endometriosis. Ann Med. 2023;55(2):2243825.
doi:10.1080/07853890.2023.2243825
2. Olivier E, Soury E, Ruminy P, et al. Fetuin-B, a second member of the
fetuin family in mammals. Biochem J. 2000;350 Pt 2(Pt 2):589-597.
3. Denecke B, Gräber S, Schäfer C, Heiss A, Wöltje M, Jahnen-Dechent W.
Tissue distribution and activity testing suggest a similar but not identical
function of fetuin-B and fetuin-A. Biochem J. 2003;376(Pt
1):135-145. doi:10.1042/BJ20030676
4. Dietzel E, Wessling J, Floehr J, et al. Fetuin-B, a liver-derived plasma
protein is essential for fertilization. Dev Cell.
2013;25(1):106-112. doi:10.1016/j.devcel.2013.03.001
5. Dietzel E, Floehr J, Van de Leur E, Weiskirchen R, Jahnen-Dechent W.
Recombinant fetuin-B protein maintains high fertilization rate in cumulus
cell-free mouse oocytes. Mol Hum Reprod. 2017;23(1):25-33.
doi:10.1093/molehr/gaw067
6. Li L, Spranger L, Stobäus N, et al. Fetuin-B, a potential link of
liver-adipose tissue cross talk during diet-induced weight loss-weight
maintenance. Nutr Diabetes. 2021;11(1):31. Published 2021 Oct 5.
doi:10.1038/s41387-021-00174-z